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[Brucella vaccination in professionally exposed subjects. Prospective study].

A Strady¹, M Lienard, J C Gillant

¹Service des Maladies infectieuses, Hôpital Robert-Debré, Reims.

Presse Medicale (Paris, France : 1983)

|September 19, 1992

Summary

This study evaluated a Brucella abortus biotype 1 (B19 strain) vaccine in 161 subjects. The vaccine showed good seropositivity and safety, but clinical effectiveness requires further investigation.

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Area of Science:

Immunology
Vaccinology
Microbiology

Background:

Brucella infections pose a significant risk to individuals with occupational exposure.
A vaccine derived from the phenol-insoluble fraction of Brucella abortus biotype 1 (B19 strain) was developed.

Purpose of the Study:

To assess the safety and immunogenicity of the B19 strain vaccine in a prospective phase IV study.
To evaluate the response to primary vaccination and booster injections.

Main Methods:

A cohort of 303 professionally exposed subjects was enrolled.
161 subjects received the B19 vaccine, with booster injections at 18 and 36 months.
Local reactions, systemic reactions, and seropositivity rates were monitored.

Main Results:

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88.5% of eligible subjects accepted vaccination.
Seropositivity reached 80% after primary vaccination.
Local pain (45.2%) and moderate systemic reactions (5%) were reported; no detectable hypersensitivity was observed.

Conclusions:

The B19 vaccine demonstrates good immunogenicity and a favorable safety profile.
Booster injections maintained seropositivity.
Further comparative studies are needed to accurately evaluate clinical effectiveness and rule out subclinical infections.