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Related Experiment Videos

Normalized regional brain atrophy measurements in multiple sclerosis.

Robert Zivadinov1, Laura Locatelli, Barbara Stival

  • 1Department of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste, Strada di Fiume, 447-34149 Trieste, Italy. zivadinov@hotmail.com

Neuroradiology
|October 11, 2003
PubMed
Summary

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Normalized brain atrophy measurements better reflect disease progression in multiple sclerosis (MS) than absolute measurements. This study found normalized regional brain parenchymal fraction (RBPF) and total regional brain volume fraction (TRBVF) correlate more strongly with MRI-defined lesions and disability in MS patients.

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Imaging Analysis

Background:

  • Measuring regional brain atrophy in multiple sclerosis (MS) studies remains controversial.
  • The utility of absolute versus normalized measurements for correlating with brain lesions and disability requires clarification.

Purpose of the Study:

  • To determine if normalized regional brain atrophy measurements correlate better with MRI-defined regional brain lesions than absolute measurements in a cross-sectional MS study.
  • To assess the relationship between normalized and absolute atrophy measurements and Expanded Disability Status Scale (EDSS) scores.

Main Methods:

  • Assessed 45 patients with relapsing-remitting MS.
  • Measured T1 and T2 lesion load (LL) and regional brain parenchymal volume (RBPV) in frontal lobes and pons using semi-automated techniques.

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  • Calculated normalized measurements: regional brain parenchymal fraction (RBPF) and total regional brain volume fraction (TRBVF).

    • Main Results:

    • Normalized measurements (RBPF, TRBVF) showed significantly better correlation with T1 and T2 lesion load in the pons and frontal lobes compared to absolute RBPV.
    • RBPF and TRBVF demonstrated stronger correlations with pontine and frontal lobe T2-LL (r=-0.37 to -0.40) and T1-LL (r=-0.27 to -0.31) than RBPV.
    • Correlations between EDSS scores and normalized atrophy measurements (RBPF, TRBVF) were more than twice as strong as correlations with absolute RBPV.

    Conclusions:

    • Normalized regional brain atrophy measurements, specifically RBPF and TRBVF, are superior to absolute measurements (RBPV) in cross-sectional MS studies.
    • These findings support the use of normalized measurements for better assessment of disease burden and its relationship to disability in MS.