[Thrombophilia as a risk factor for central retinal vein occlusion]

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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Anetta Undas1, Agnieszka Kubicka-Trzaska

  • 1II Katedry Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.

Klinika Oczna
|October 14, 2003
PubMed

Central retinal vein occlusion is associated with systemic conditions, such as arterial hypertension, diabetes, hypercholesterolemia, but also with certain hypercoagulability states (thrombophilia). Growing evidence indicates, that the presence of antiphospholipid antibodies and elevated plasma homocysteine levels predispose to central retinal vein occlusion. In younger patients, factor V Leiden (Arg506Gln) could increase the risk of this disease. Other probable causes of thrombophilia related to retinal vein occlusion include increased levels of plasminogen activator inhibitor 1 and lipoprotein (a), which impair fibrinolysis.

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