Related Experiment Video

Updated: Jul 6, 2026

Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry
08:21

Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry

Published on: September 1, 2019

Polyamine depletion and drug-induced chromosomal damage: new results

P J Tofilon, D F Deen, L J Marton

    Science (New York, N.Y.)
    |November 20, 1992
    PubMed
    Abstract

    No abstract available in PubMed .

    More Related Videos

    Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
    13:09

    Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

    Published on: March 3, 2023

    Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
    05:34

    Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes

    Published on: July 14, 2023

    Related Experiment Videos

    Last Updated: Jul 6, 2026

    Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry
    08:21

    Cell Cycle-specific Measurement of γH2AX and Apoptosis After Genotoxic Stress by Flow Cytometry

    Published on: September 1, 2019

    Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
    13:09

    Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

    Published on: March 3, 2023

    Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
    05:34

    Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes

    Published on: July 14, 2023

    Related Concept Videos

    Drug Toxicity: Dose-Dependent Reactions01:24

    Drug Toxicity: Dose-Dependent Reactions

    Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

    Articles linked to this work by shared authors, journal, and citation graph.

    The addition of Valproic acid to concurrent radiation therapy and temozolomide improves patient outcome: a Correlative analysis of RTOG 0525, SEER and a Phase II NCI trial.

    Cancer studies and therapeutics·2021

    Polyamine-DNA Interactions: Possible Site of New Cancer Chemotherapeutic Intervention.

    Pharmaceutical research·2013

    In Vitro Cytotoxic Effects of Dibromodulcitol in 9L Rat Brain Tumor Cells.

    Pharmaceutical research·2013

    The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer.

    Cancer chemotherapy and pharmacology·2009

    Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs.

    Amino acids·2007

    Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs.

    Molecular pharmacology·2005

    Psychedelics as prophylactic neuroprotectants.

    Science (New York, N.Y.)·2026

    Not such a benign colonizer.

    Science (New York, N.Y.)·2026

    Tumors steal a signal from T cells.

    Science (New York, N.Y.)·2026

    Locking aligned molecular dipoles.

    Science (New York, N.Y.)·2026

    Building a scalable climate coalition for heavy industry.

    Science (New York, N.Y.)·2026

    Spontaneous polarization in chemical vapor-deposited polymer films creates large electric fields.

    Science (New York, N.Y.)·2026

    Efficacy and safety of ecopipam for Tourette syndrome: An updated systematic review and meta-analysis of randomized controlled trials.

    Therapeutic advances in psychopharmacology·2026

    Stapler vs. sleeve circumcision for multiple penile condylomata acuminata: a comparative study.

    Frontiers in surgery·2026

    Development of Lyophilized Ebastine-Loaded Novasome Tablets: Comprehensive Physicochemical Characterization and In Vitro/In Vivo Release Evaluation.

    Recent advances in drug delivery and formulation·2026

    Molecularly Imprinted Polymers for Steroid Hormone Analysis: Design Strategies, Recognition Mechanisms, and Detection Applications.

    Journal of separation science·2026

    A SIRIUS-Guided Integrative Modificomics and Oligosaccharidomics (SGIMO) strategy unveils bioactive modified metabolites in Chinese rice wine.

    Food research international (Ottawa, Ont.)·2026

    Integrating cytotoxicity and NMR-based metabolomics to uncover bioactive aporphine alkaloids and pentacyclic triterpenoids from Siparuna guianensis.

    Natural product research·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us