Related Experiment Videos
Histiocytic lesions involving the bone marrow
Karen L Chang1, Karl K Gaal, Qin Huang
1Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. kchang@coh.org
Seminars in Diagnostic Pathology
|October 14, 2003
Summary
Bone marrow examination is key for diagnosing histiocytic disorders, including storage diseases and hemophagocytic syndromes. While rare, malignant histiocytic conditions like Langerhans cell histiocytosis can also be identified.
Area of Science:
- Hematology
- Pathology
- Oncology
Background:
- Histiocytic lesions in bone marrow encompass reactive and neoplastic conditions.
- Bone marrow examination is crucial for diagnosing various histiocytic and monocytic disorders.
- Granulomas and storage disorders may present initially in the bone marrow.
Purpose of the Study:
- To review the morphologic, immunophenotypic, and genotypic characteristics of bone marrow histiocytic lesions.
- To highlight the diagnostic significance of bone marrow examination for histiocytic and monocytic diseases.
- To discuss the spectrum of histiocytic disorders affecting the bone marrow.
Main Methods:
- Review of literature on histiocytic lesions of the bone marrow.
- Analysis of morphologic, immunophenotypic, and genotypic features.
- Discussion of diagnostic criteria and clinical implications.
Main Results:
- Bone marrow examination aids in diagnosing lysosomal storage disorders and hemophagocytic syndromes.
- Granulomas in bone marrow can indicate systemic diseases.
- Malignant histiocytic disorders, such as Langerhans cell histiocytosis, are rare in bone marrow, except for monocytic leukemias.
Conclusions:
- Bone marrow pathology is essential for identifying a range of histiocytic and monocytic conditions.
- Understanding the diverse features of these lesions improves diagnostic accuracy.
- Langerhans cell histiocytosis is the most frequent malignant histiocytic disorder in the bone marrow.