Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Characterization of experimental equine glanders.

Jose Lopez1, John Copps, Catherine Wilhelmsen

  • 1National Centre for Foreign Animal Disease, 1015 Arlington St., Suite T2300, Winnipeg, Man., Canada R3E 3M4.

Microbes and Infection
|October 14, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virulence of Burkholderia pseudomallei Strains from Western Hemisphere and Africa in Mice.

Emerging infectious diseases·2026
Same author

Characterization of an isogenic <i>bimA</i> mutant in the ATS2021 strain of <i>Burkholderia pseudomallei</i>.

Infection and immunity·2026
Same author

Severe hypertriglyceridemia due to heterozygous LPL variant, ApoE ε2ε2 genotype, and environmental interactions in an 11-year-old boy.

Journal of clinical lipidology·2026
Same author

Resisting disenfranchized grief in the context of perinatal death: A qualitative study on the social labor of bereaved mothers.

Death studies·2026
Same author

Small peptide P110 mitigates axonal degeneration of SPG15 patient iPSC-derived neurons by targeting mitochondrial dysfunction.

Neurobiology of disease·2025
Same author

Between Two Signals: The Intersection of Electrophysiology and Heart Failure.

Journal of cardiac failure·2025

Researchers developed a horse model for glanders, a disease caused by Burkholderia mallei. This model aids in studying disease pathogenesis and developing effective vaccines against glanders.

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Bacteriology

Background:

  • Burkholderia mallei causes glanders, a significant disease in equids.
  • Small animal models have advanced understanding of B. mallei pathogenesis.
  • Challenges exist in active immunization studies using small animals.

Purpose of the Study:

  • To establish and validate a horse model for studying glanders.
  • To investigate the pathogenesis of B. mallei infection in the target species.
  • To facilitate vaccine development for glanders.

Main Methods:

  • Experimental infection of horses with B. mallei via intratracheal inoculation.
  • Clinical observation and microbiological assessment of infected horses.
  • Evaluation of the horse model for pathogenesis and vaccine studies.

Related Experiment Videos

Main Results:

  • Intratracheal B. mallei inoculation successfully induced clinical glanders in horses.
  • B. mallei was recovered from tissues of infected horses, confirming systemic spread.
  • The developed model demonstrated the feasibility of studying glanders in equids.

Conclusions:

  • The horse model is a valuable tool for glanders research.
  • This model supports further investigation into B. mallei pathogenesis.
  • It is crucial for advancing vaccine development against glanders.