Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human exposure assessment. II: Quantifying and reducing the uncertainties.

G K Whitmyre1, J H Driver, M E Ginevan

  • 1Technology Sciences Group Inc. Washington, D.C. 20036.

Toxicology and Industrial Health
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

System Dynamics Modeling of Caries Severity States in Long-Term Care.

Journal of dental research·2024
Same author

Applying Social Practice Theory to Explore Australian Preschool Children's Oral Health.

JDR clinical and translational research·2024
Same author

The oral health of adults with learning disabilities: A secondary analysis of the Adult Dental Health Survey 2009.

Community dental health·2024
Same author

Exploring experiences of living with removable dentures-A scoping review of qualitative literature.

Gerodontology·2024
Same author

Development and psychometric validation of the gum health experience questionnaire.

Journal of clinical periodontology·2023
Same author

Gum health and quality of life-subjective experiences from across the gum health-disease continuum in adults.

BMC oral health·2022

This study surveys alternative human exposure assessment methods to reduce uncertainty. It highlights using realistic scenarios, stochastic modeling, and physiological data for more accurate exposure estimates.

Area of Science:

  • Environmental Health
  • Toxicology
  • Risk Assessment

Background:

  • Traditional human exposure assessment often relies on extreme estimates, leading to uncertainty.
  • The Maximally Exposed Individual (MEI) approach may not accurately represent real-world exposures.

Purpose of the Study:

  • To survey and illustrate alternative methods for human exposure assessment.
  • To reduce and quantify uncertainties associated with exposure estimates.
  • To improve the accuracy and reliability of exposure assessments.

Main Methods:

  • Utilizing appropriate default exposure parameter values.
  • Incorporating time-activity data for exposure duration.
  • Employing reasonable exposure scenarios instead of the MEI approach.

Related Experiment Videos

  • Applying stochastic methods like Monte Carlo simulations.
  • Conducting bivariate analysis for parameter interdependencies.
  • Considering less-than-lifetime exposure durations.
  • Integrating physiological factors and pharmacokinetic models for absorbed dose estimation.

    • Main Results:

    • Alternative methods offer improved quantification of exposure uncertainties.
    • Realistic exposure scenarios and stochastic modeling provide more nuanced estimates.
    • Incorporation of physiological data enhances absorbed dose accuracy.

    Conclusions:

    • Adopting these alternative methods can lead to more robust and reliable human exposure assessments.
    • Further research is needed to refine these approaches and address sensitive subpopulations.