Related Experiment Video
Updated: Aug 30, 2026
Laparoscopic Oocyte Retrieval and Cryopreservation during Vaginoplasty for Treatment of Mayer-Rokitansky-Kuster-Hauser Syndrome
Published on: May 10, 2022
Partners of men with Klinefelter syndrome can benefit from assisted reproductive technologies
Ulun Ulug1, Faruk Bener, Mehmet Ali Akman
1Bahceci Women Health Care Center and German Hospital at Istanbul, Istanbul, Turkey
Objective:
To report the birth of a healthy female infant from a father with nonmosaic Klinefelter syndrome (KS) and document the experience of men with KS undergoing assisted conception.
Design:
Retrospective.
Setting:
Private IVF center.
Patient(S):
Twelve couples with male factor infertility due to Klinefelter syndrome undergoing assisted reproduction treatment.
Intervention(S):
Controlled ovarian hyperstimulation, testicular sperm extraction, intracytoplasmic sperm injection (ICSI), round spermatid injection (ROSI), and preimplantation genetic diagnosis.
Main Outcome Measure(S):
Testicular sperm retrieval rate, fertilization rate, and pregnancy outcome.
Result(S):
There was a sufficient amount of motile sperm for injection into mature oocytes in 6 of the 11 testicular biopsies (54.5%). Fertilization rates for ICSI and ROSI cases were 54.2% and 41.6%, respectively. The pregnancy rate per ET was 27.2%. None of the ROSI cases resulted in pregnancy. Two patients had spontaneous abortions at 8 and 18 weeks of gestation, respectively. Only one patient delivered a healthy female baby after 36 weeks of an uneventful pregnancy.
Conclusion(S):
Men with KS can benefit from assisted reproductive technologies, and the testicular sperm retrieval rate among them is promising. Although sex chromosome aberrations among the embryos from men with KS are not common, couples can be offered preimplantation genetic diagnosis before ET.
Related Concept Videos
01:23Infertility in Males
02:28Sex-linked Disorders
01:41Spermatogenesis
02:28Sex Linked Disorders
02:19The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...