An intensity-dependent biphasic neuron in mudpuppy retina
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Updated: Oct 23, 2026

Using the Horseshoe Crab, Limulus Polyphemus, in Vision Research
Published on: July 2, 2009
1Department of Physiology, University of Michigan Medical School, Ann Arbor 48109-0622.
Abstract:
Intracellular recordings in dark-adapted mudpuppy retinas have revealed a type of infrequently encountered cell with unusual response properties. These cells may be a subclass of horizontal cell since they are encountered at the same depth as horizontal cells and have large receptive fields and response amplitudes. However, they differ from typical horizontal cells in that they are depolarized by low intensity illumination and hyperpolarized by higher intensity illumination at all wavelengths. Both types of responses appear to be driven mainly by 572 nm cones. Both the depolarizing and hyperpolarizing responses were unaffected by APB, indicating that they are not mediated by on-center bipolar cells.
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