Related Experiment Video
Updated: Aug 30, 2026

Rescue of Recombinant Newcastle Disease Virus from cDNA
Published on: October 11, 2013
Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation
Jason J Rodriguez1, Lin-Fa Wang, Curt M Horvath
1Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA.
Abstract:
The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
The JAK-STAT Signaling Pathway
Inhibitors of Virion Maturation and Assembly
Inhibitors Of Virion Release
Viruses with RNA Genomes
Hepatitis

