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[Comparative choleretic properties of natural xanthone compounds from Gentianopsis barbata]
S M Nikolaev1, Z G Sambueva, A V Tsyrenzhapov
1Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, ul. Sakh'yanova 6, Ulan-Ude, 670047 Russia.
Abstract:
Comparative data are presented for the choleretic activity of xanthones isolated from Gentianopsis barbata (Froel.) Ma. (Gentianaceae family): a sum of xanthone glycosides (I) and aglycons (II); xanthone aglycons, including decussatin [1-(OH)-3,7,8-(OCH3)3] (III) and gentiacaulein [1,7-(OH)-3,8-(OCH3)2] (IV); and xanthone glycoside gentiabavaroside [1-O-primverosyl-7-(OH)-3,8-(OCH3)2] (V). It was established that (II) is superior to (I) with respect to cholagogic effect and is inferior to (III) and (IV) with respect to cholatostimulant action.
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