Late development of frontal prolactinoma after resection of pituitary tumor

The unusual case of a patient with a frontal lobe prolactinoma developed 14 years after resection of a histologically benign pituitary adenoma is presented. Sixteen years after resection of this frontal mass, and 30 years after the first intervention, the patient is symptom-free and without evidence of new intracranial tumors. The possibility that frontal tumor resulted as the late proliferation of microscopic tumor seeding that took place in the course of the first surgery, is suggested. Although this case can be considered as a pituitary carcinoma, the clinical course supports that tumor seeding from pituitary tumors not necessarily indicates a poor prognosis.