Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat
Related Experiment Video
Updated: Aug 30, 2026

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
Published on: June 6, 2015
Masaaki Arai1, Shigeru Amano, Akihide Ryo
1Department of Biochemistry II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-0042, Japan.
Abstract:
Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.
More Related Videos
09:46Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
09:07Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017