Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microbial globins.

Guanghui Wu1, Laura M Wainwright, Robert K Poole

  • 1Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, England, UK.

Advances in Microbial Physiology
|October 17, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning enables rabies virus detection and antibody quantification in cell culture.

Scientific reports·2026
Same author

Integrating Bone-Brain Axis Modulation and Tea Consumption for Enhancing Neurovascular Resilience and Patient Rehabilitation Education.

Food science & nutrition·2026
Same author

Artificial Intelligence with Robotics for Metabolic Rehabilitation and Enhanced Patient Recovery in Critical Care.

Research (Washington, D.C.)·2026
Same author

Decoding spontaneous intracerebral hemorrhage: mechanistic breakthroughs and disruptive revolution in pharmacological treatment.

Experimental & molecular medicine·2026
Same author

Synergistic interactions of ruthenium-based carbon monoxide-releasing molecules and antibiotics in their effects on <i>Escherichia coli</i>.

Microbiology (Reading, England)·2026
Same author

Applications of Robotic Exoskeletons as Motion-Assistive Systems in Cancer Rehabilitation.

Research (Washington, D.C.)·2025
Same journal

Extracellular electron transfer: From early life to modern biogeochemistry and applications.

Advances in microbial physiology·2026
Same journal

From feeding cell to fruiting body: Multidrug transport in the life cycle of Dictyostelium discoideum.

Advances in microbial physiology·2026
Same journal

Steroids as antibacterials.

Advances in microbial physiology·2026
Same journal

Polyhydroxyalkanoates as ecological currencies across the microbial tree of life.

Advances in microbial physiology·2026
Same journal

The physiology and biochemistry of oxidative stress in bacteria.

Advances in microbial physiology·2026
Same journal

Nitrate reduction for survival in a nanomolar world, not the millimolar world of a laboratory.

Advances in microbial physiology·2025
See all related articles

Microbial globins, once overlooked, are now recognized for diverse functions, particularly protecting against nitric oxide (NO) stress. Understanding these proteins offers biotechnological and medical applications.

Area of Science:

  • Biochemistry
  • Microbiology
  • Protein Science

Background:

  • Globins are ancient, diverse proteins, with microbial forms recently gaining attention.
  • Microbial globins exhibit structural diversity and are crucial for fulfilling specific functions.
  • A key role identified is protection against nitric oxide (NO) related stresses.

Purpose of the Study:

  • To review the structural diversity and functional roles of microbial globins.
  • To highlight the significance of microbial globins in NO metabolism and stress protection.
  • To explore the potential biotechnological and medical applications of microbial globins.

Main Methods:

  • Comparative analysis of globin structures and sequences.
  • Review of literature on microbial globin functions, particularly in NO metabolism.

Related Experiment Videos

  • Identification and characterization of different microbial globin classes.

    • Main Results:

    • Three main classes of microbial globins are recognized: Vitreoscilla-like hemoglobin (Vgb), truncated globins, and flavohaemoglobins.
    • Vgb shows potential for biotechnological applications in improving host cell growth and metabolism.
    • Truncated globins and flavohaemoglobins are involved in oxygen and NO metabolism, with flavohaemoglobins offering protection from nitrosative stresses.

    Conclusions:

    • Microbial globins possess diverse structures and functions, with significant roles in NO detoxification.
    • Further understanding of microbial globins can lead to advancements in controlling pathogenic bacteria and in biotechnology.
    • Exploration of microbial globins' enzymatic capabilities may reveal novel functions beyond NO protection.