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Related Experiment Videos

The CD95 type I/type II model.

Bryan C Barnhart1, Elizabeth C Alappat, Marcus E Peter

  • 1The Ben May Institutefor Cancer Research, University of Chicago, 924 E. 57th Street, Chicago, IL 60637, USA.

Seminars in Immunology
|October 18, 2003
PubMed
Summary
This summary is machine-generated.

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CD95 (APO-1/Fas) receptor initiates apoptosis via extrinsic and intrinsic pathways. This review details the cross-talk between these CD95-mediated cell death routes, distinguishing Type I and Type II cells.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • CD95 (APO-1/Fas) is a key death receptor initiating the extrinsic apoptosis pathway.
  • The extrinsic pathway involves caspase-8 activation within the death-inducing signaling complex (DISC).
  • The intrinsic pathway originates intracellularly, involving mitochondrial factors and caspase-9 activation in the apoptosome.

Purpose of the Study:

  • To review recent advancements in understanding CD95-mediated apoptosis.
  • To delineate the biochemistry and physiological functions of CD95's extrinsic and intrinsic pathways.
  • To explore the cross-talk mechanisms between the extrinsic and intrinsic apoptosis pathways.

Main Methods:

  • Literature review of recent developments in apoptosis research.

Related Experiment Videos

  • Analysis of biochemical mechanisms governing CD95 signaling.
  • Comparison of Type I and Type II cell death responses mediated by CD95.

    • Main Results:

    • Identified CD95 as a prototype death receptor activating the extrinsic apoptosis pathway.
    • Described the intrinsic apoptosis pathway initiated by intracellular events and mitochondrial factors.
    • Highlighted the cross-talk between extrinsic and intrinsic pathways, notably via Bid cleavage by caspase-8.

    Conclusions:

    • CD95 signaling involves complex interactions between extrinsic and intrinsic apoptosis pathways.
    • Bid acts as a crucial link, connecting caspase-8 activity to mitochondrial events.
    • Cells are classified as Type I or Type II based on their reliance on mitochondrial support for CD95-induced death.