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Related Concept Videos

Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 17, 2026

Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
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Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation

Published on: January 14, 2011

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Despoina Xanthopoulou1, Maria Crespo2, Lydia Kalafati1

  • 1Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Dresden 01307, Germany; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden 01328, Germany.

Seminars in Immunology
|June 15, 2026
PubMed
Summary

Interleukin-1 (IL-1) reprograms stem cells, influencing immune cell production and function. This process impacts cancer development and progression, suggesting IL-1 as a therapeutic target.

Keywords:
Cancer progressionEmergency myelopoiesisHematopoietic reprogrammingIL-1 signalingInflammatory memorySystemic inflammation

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Area of Science:

  • Immunology
  • Hematopoiesis
  • Cancer Biology

Background:

  • Interleukin-1 (IL-1) is crucial for innate immunity and inflammation.
  • IL-1 systemically regulates hematopoietic stem and progenitor cells (HSPCs).
  • Tumors are inflammatory entities influencing hematopoiesis.

Purpose of the Study:

  • To discuss IL-1 signaling in emergency myelopoiesis and inflammatory memory.
  • To explore how IL-1-mediated hematopoietic reprogramming influences cancer progression.
  • To highlight therapeutic strategies targeting IL-1.

Main Methods:

  • Review of existing literature on IL-1 signaling in hematopoiesis and cancer.
  • Analysis of IL-1's role in emergency myelopoiesis and inflammatory memory.
  • Discussion of epigenetic, metabolic, and transcriptomic changes induced by IL-1.

Main Results:

  • IL-1 induces durable changes in HSPCs, affecting myeloid progeny.
  • IL-1 signaling contributes to an immunosuppressive phenotype in myeloid cells within tumors.
  • Chronic inflammation and IL-1 signaling may promote clonal hematopoiesis and cancer susceptibility.

Conclusions:

  • IL-1 signaling plays a significant role in shaping immune responses and influencing cancer progression.
  • Targeting IL-1-mediated hematopoietic reprogramming offers potential therapeutic avenues.
  • Understanding IL-1's systemic effects is key to managing inflammation-associated diseases and cancers.