Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risks of transfusion-transmitted infections: 2003.

Gregory J Pomper1, YanYun Wu, Edward L Snyder

  • 1Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Current Opinion in Hematology
|October 18, 2003
PubMed
Summary

Emerging infectious diseases pose new threats to blood transfusion safety. Donor screening and nucleic acid testing help mitigate risks from viruses like HIV and Hepatitis C, but challenges remain for Hepatitis B and other novel pathogens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ferritin Levels Following Postpartum Hemorrhage: A Case Series.

A&A practice·2026
Same author

Variation in Chronic Automated Red Cell Exchange Practices for Sickle Cell Disease: Insights Into Isovolemic Hemodilution Use.

Journal of clinical apheresis·2026
Same author

A randomized, double-blind, controlled, parallel group study with amustaline/glutathione pathogen reduced red blood cells in regions at potential risk for Zika virus transfusion-transmitted infections (RedeS Study)-protocol for a phase 3 clinical trial.

Trials·2026
Same author

Effects of lower limb exoskeleton robot-assisted rehabilitation on motor function, activities of daily living, and electromyography in hemiplegic stroke: a randomized controlled trial.

BMC neurology·2026
Same author

Pathogen-reduced Red Cells in Cardiac Surgery: Reply.

Anesthesiology·2026
Same author

Severity of admission anemia and risk of postpartum hemorrhage: a single-center retrospective cohort study (2024-2025).

International journal of obstetric anesthesia·2026

Area of Science:

  • Infectious Diseases
  • Public Health
  • Transfusion Medicine

Background:

  • While transfusion-transmitted infections (TTIs) like HIV and Hepatitis C have decreased due to advanced screening, new infectious disease threats to blood safety are emerging.
  • Nucleic acid testing (NAT) has significantly reduced the risk of HIV and Hepatitis C transmission.

Purpose of the Study:

  • To review current risks of transfusion-transmitted infections, including established and emerging pathogens.
  • To assess the effectiveness of current screening methods and identify gaps in blood safety protocols.

Main Methods:

  • Review of existing literature and data on TTIs.
  • Analysis of transfusion safety risks based on American Red Cross estimates and implemented testing protocols.
  • Identification of pathogens for which screening tests are not yet available.

Related Experiment Videos

Main Results:

  • The estimated risk of transfusion-transmitted HIV is 1:1,215,000 and Hepatitis C is 1:1,935,000 per unit transfused.
  • Hepatitis B virus (HBV) poses a relatively high risk (1:205,000) due to lack of widespread NAT implementation.
  • Risks for human T-cell leukemia virus I/II are estimated at 1:2,993,000; West Nile virus testing is in place, but tests for Chagas disease, malaria, SARS, and vCJD are unavailable.

Conclusions:

  • Donor deferral based on behavior and travel history is a key strategy for preventing TTIs.
  • Continued vigilance and development of new screening technologies are crucial to address emerging infectious disease threats in transfusion medicine.