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Updated: Jul 3, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Ferritin Levels Following Postpartum Hemorrhage: A Case Series.

Jean-Paul Russo1, Jennifer M Banayan2, Karlyn A Martin3

  • 1From the Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida.

A&A Practice
|July 2, 2026
PubMed
Summary

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Postpartum hemorrhage (PPH) can worsen iron deficiency anemia. In iron-deficient women with PPH, ferritin levels remained a reliable indicator of low iron stores, suggesting its continued utility in acute settings.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Maternal Health

Background:

  • Postpartum hemorrhage (PPH) is a significant cause of maternal morbidity and mortality.
  • PPH can exacerbate iron deficiency anemia, a common complication in pregnant individuals.
  • Ferritin is the primary biomarker for iron deficiency, but its reliability during acute PPH is uncertain due to its acute-phase reactant properties.

Purpose of the Study:

  • To evaluate the reliability of ferritin as a biomarker for iron deficiency in women experiencing acute postpartum hemorrhage (PPH).
  • To assess if ferritin levels remain indicative of iron deficiency despite the acute inflammatory response associated with PPH.

Main Methods:

  • A case series involving 10 women with pre-existing iron deficiency who experienced PPH following cesarean delivery.

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Last Updated: Jul 3, 2026

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  • Postoperative ferritin levels were measured and analyzed in the context of PPH.

    • Main Results:

    • All 10 iron-deficient women maintained preoperative ferritin levels below 30 µg/mL postoperatively, even after experiencing acute PPH.
    • Ferritin levels consistently reflected pre-existing iron deficiency in this cohort during the acute PPH setting.

    Conclusions:

    • Ferritin appears to remain a reliable marker for identifying iron deficiency in women with pre-existing deficiency, even in the acute phase of postpartum hemorrhage.
    • Further large-scale, prospective studies are warranted to definitively validate ferritin's role in monitoring iron status following PPH.