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Updated: Aug 18, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Acute lymphocytic leukemia: role of hematopoietic stem cell transplantation in current management
1Department of Hematology and Bone Marrow Transplantation, Ramban Medical Center & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. I_avivi@rambam.health.gov.il
Purpose Of Review:
It is still unclear what the best postremission therapy is for young adults with acute lymphocytic leukemia (ALL). Encouraging results, supporting the superiority of allogeneic stem cell transplantation in CR1 compared with chemotherapy/ allogeneic stem cell transplantation (ASCT), are coming from the ongoing international prospective MRC UKALL XII /ECOG 2993 study. However, the transplant-related morbidity and mortality remain high.
Recent Findings:
The detection of persistent minimal residual disease (MRD) after induction and consolidation therapy is being increasingly used to identify high-risk patients for whom allogeneic transplant may offer the only curative option.
Summary:
The ultimate aim is to determine whether the absence of MRD pretransplant can be used as a surrogate for low-risk adult ALL that can be cured without allogeneic transplantation.
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