Related Experiment Video
Updated: Aug 30, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Comparison of long-term fluctuations: laser scanning tomography versus automated perimetry
1University Eye Clinic, University of Freiburg, Killianstr 5, 79106 Freiburg, Germany. funk@aug.ukl.uni-freiburg.de
Background:
The aim of our study was to investigate the long-term variability of laser scanning tomography and to compare it with the long-term variability of automated perimetry.
Method:
We retrospectively reviewed the charts of 199 patients (394 eyes) who underwent both automated perimetry (Octopus) and laser scanning tomography (Heidelberg retina tomograph, HRT) in our hospital since 1994. All patients either had ocular hypertension (OHT) or early stage glaucoma. The mean follow-up time was 5.4 years; the average number of examinations was 7.7. The variability was described by the variance ratio VR.
Results:
The HRT parameters showed very similar long-term fluctuations as the Octopus parameters. In detail: VR of HRT parameters ranged from 0.04 (cup area, cup volume, mean cup depth) to 0.35 (contour height variation), whereas VR of Octopus parameters ranged from 0.12 (mean sensitivity) to 0.15 (loss variance).
Conclusions:
The long-term variability of HRT parameters is in the same range as the long-term variability of visual field parameters. Since it is now widely accepted that visual field changes over time should be reproduced at least once or twice before clinical consequences can be drawn, the same should be postulated for HRT changes over time.
