Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Computer modeling the cytochrome P450 three-dimensional structure: problems and prospects].

A S Ivanov1, V S Skvortsov, A A Sechenykh

  • 1Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, Pogodinskaya str. 10, Moscow, 119121, Russia. ivanov@ibmh.msk.su

Biomeditsinskaia Khimiia
|October 21, 2003
PubMed
Summary

This review covers computer modeling of cytochrome P450 (P450) 3D structures, detailing methods, challenges, and future directions for accurate protein modeling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

MicroRNA: role in pathogenesis, problems of microRNA therapy, and future prospects.

Biomeditsinskaia khimiia·2026
Same author

Identification of proteins with altered PTM levels in patients with temporal lobe epilepsy in different regions of the human brain.

Biomeditsinskaia khimiia·2026
Same author

The Microbiomic Metaproteome of the Taiga Tick Ixodes persulcatus from the Tyumen Region.

Acta naturae·2026
Same author

[Endovascular treatment of paraprosthetic false aneurysm of the proximal anastomosis after aortobifemoral repair for an abdominal aortic aneurysm].

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery·2026
Same author

Identification of proteins with variable levels of post-translational modifications in human temporal lobe epilepsy.

Biomeditsinskaia khimiia·2025
Same author

Vitaphospholip® (water-soluble phosphatidylcholine) in the treatment of combined hyperlipidemia: a randomized, placebo-controlled clinical trial.

Biomeditsinskaia khimiia·2025

Area of Science:

  • Biochemistry and computational biology
  • Protein structure analysis
  • Enzyme function and modeling

Context:

  • Cytochromes P450 (P450s) are crucial enzymes with complex 3D structures.
  • Accurate structural models are essential for understanding P450 function and drug interactions.
  • Computer molecular modeling offers powerful tools for P450 research.

Purpose:

  • To review fundamental approaches to computer modeling of P450 3D structures.
  • To identify challenges and outline prospects in P450 homology modeling.
  • To provide guidance on model refinement and verification.

Summary:

  • The review discusses the role of computer molecular modeling in P450 research.
  • It details the stages, purposes, and tasks of homology modeling for protein structures.

Related Experiment Videos

  • Key challenges, criteria for success, and methods for refinement and verification of P450 models are addressed.

    • Impact:

    • Facilitates improved understanding of P450 enzyme mechanisms.
    • Aids in the rational design of drugs targeting P450s.
    • Enhances the reliability of computational predictions in P450 research.