Commercial-scale synthesis of protected 2'-deoxycytidine and cytidine nucleosides
Kikkeri J Divakar1, Chitra M Sawant, Y A Mulla
1Research and Development, Innovasynth Technologies (India) Limited, (Formerly a Division of Indian Organic Chemicals Limited), Khopoli District, Raigad, Maharashtra, India. divakj@yahoo.com
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2003
Abstract:
Transformation of 2'-deoxyuridine and uridine analogs to protected 2'-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale-up.
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