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Updated: Aug 30, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of 2'-deuterio and 3'-deuterio cytidine 5'-diphosphate
Jessica Sandbrink1, Roger Strömberg
1Division of Organic and Bioorganic Chemistry, MBB Scheele Laboratory, Karolinska Institute, Stockholm, Sweden.
Abstract:
2'-2H- and 3'-2H-CDP were synthesized from 5'-MMT-3'-O-TBDMS and 2',5'-O-diTBDMS cytidine derivatives, respectively, by oxidation followed by acidic removal of 5'-protection, reduction with [NaBD(OAc)3] and finally displacement of a tosyl group by pyrophosphate.
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