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Updated: Aug 30, 2026
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Linear polyethylenimine as a tool for comparative studies of antisense and short double-stranded RNA oligonucleotides
Jean-Charles Bologna1, Gabriele Dorn, Francois Natt
1Functional Genomics, Novartis Pharma AG, Basel, Switzerland.
Abstract:
Despite the recently enlarged field of available RNA knock-down technologies, e.g., antisense oligonucleotides (ASOs) and duplexes of synthetic 21 nucleotides RNAs (siRNAs), no versatile transfection reagent has been reported to deliver different nucleic acids formats at high rates of efficiency. We have evaluated the versatility and efficacy of linear PEI in transfecting and properly delivering a broad panel of nucleic acids such as short oligonucleotides and double-stranded RNA into cells in culture.
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