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Related Experiment Videos

Omeprazole-induced intractable cough.

Mehran Howaizi1, Christian Delafosse

  • 1Gastroenterology and Hepatology Department, Simone Veil Hospital, Eaubonne, France. mehran.howaizi@ch-eaubonne-montmorency.fr

The Annals of Pharmacotherapy
|October 21, 2003
PubMed
Summary

Omeprazole therapy can cause a chronic, persistent cough as a side effect. Discontinuing the medication resolved the cough, highlighting the need for clinical awareness of this adverse drug reaction.

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Area of Science:

  • Pharmacology
  • Pulmonology
  • Gastroenterology

Background:

  • Proton pump inhibitors like omeprazole are commonly prescribed for gastroesophageal reflux disease (GERD).
  • Chronic cough has multiple potential causes, including GERD, asthma, and postnasal drip syndrome.

Observation:

  • A 42-year-old woman developed a persistent, dry cough after initiating omeprazole for postoperative heartburn.
  • The cough persisted for four months, despite initial suspicion of GERD, and resolved only after discontinuing omeprazole.

Findings:

  • A causal relationship between omeprazole use and the patient's chronic cough was established.
  • While cough is listed as a rare adverse effect of omeprazole in the US, it is infrequently reported internationally.

Implications:

  • Clinicians should consider omeprazole-induced cough as a potential diagnosis in patients with unexplained chronic cough.
  • Recognizing this adverse drug effect can prevent unnecessary diagnostic procedures and improve patient management.

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