[Perioperative immune modulation in renal cell carcinoma--review of the current situation]
M Böhm1, T Klatte, E P Allhoff
1Urologische Klinik, Otto-von-Guericke Universität, Leipziger Str. 44, 39120 Magdeburg. malte.boehm@medizin.uni-magdeburg.de
Abstract:
Surgery and immunotherapy are the mainstay in the treatment of renal cell carcinoma. Surgery, however, is associated with considerable perioperative immunodysfunction. This immunodysfunction can be modulated by pretreatment with Interleukin-2 (IL-2), which appears to prolong tumour-specific survival. Perioperative immunomodulation could help close the therapeutic gap between neoadjuvant and adjuvant immunotherapy. This article reviews recent literature and presents original data of 63 patients.
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