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Serum intercellular adhesion molecule-1 levels in acute rheumatic fever
Ibrahim H Yaman1, Ayhan Dagdemir, Kemal Baysal
1Department of Paediatrics, Medical Faculty, Ondokuz Mayis University, Samsun, Turkey.
Annals of Tropical Paediatrics
|October 22, 2003
Summary
Serum soluble intercellular adhesion molecule-1 (sICAM-1) is elevated in acute rheumatic fever (ARF) patients, even in remission. sICAM-1 levels may indicate ARF improvement when other markers normalize.
Area of Science:
- Immunology
- Rheumatology
- Pediatrics
Background:
- Acute rheumatic fever (ARF) is an inflammatory condition following streptococcal infection.
- The role of soluble intercellular adhesion molecule-1 (sICAM-1) in ARF pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the role of sICAM-1 in the pathogenesis and clinical course of ARF.
- To assess sICAM-1 serum levels in ARF patients during different disease phases.
Main Methods:
- Serum sICAM-1 levels were measured in 30 ARF patients (active, remission, inactive phases).
- Levels were compared to 20 patients with prior ARF and 20 healthy controls.
- Erythrocyte sedimentation rate (ESR) and fibrinogen were also monitored.
Main Results:
- ARF patients showed significantly increased sICAM-1 levels during the active phase.
- sICAM-1 levels decreased during remission but remained elevated in the inactive phase compared to controls.
- Patients with prior ARF had sICAM-1 levels similar to healthy controls.
Conclusions:
- sICAM-1 plays a role in ARF pathogenesis.
- Serum sICAM-1 levels may serve as a marker for ARF improvement, potentially indicating disease resolution even when conventional markers normalize.