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Updated: Aug 30, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
A case of mixed connective tissue disease showing a lymphoid follicle in muscle pathology
Chieko Inoue1, Yoshio Ikeda, Makoto Tanaka
1Department of Neurology, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511 Maebashi, Japan.
Abstract:
We report a 74-year-old man suffering from mixed connective tissue disease (MCTD) accompanied by a lymphoid follicle in muscle pathology. He showed proximal muscle weakness and arthritis in finger joints. His laboratory findings were characteristic of MCTD. Prednisolone administration favorably improved his symptoms. A lymphoid follicle is a rare pathological finding in inflammatory myopathies. The immunohistochemical findings suggest that the lymphoid follicle would be involved in the specific role for the pathogenesis of MCTD.
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