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Updated: Jul 8, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
New tools for functional mammalian cancer genetics
Thijn R Brummelkamp1, René Bernards
1Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Abstract:
Knowledge of the function of individual genes that encode components of cell-signalling pathways is crucial to our understanding of normal growth control and its deregulation in cancer, but we have functional information for only 15% of human genes at present. Several new technologies have recently become available to identify gene function in mammalian cells using high-throughput genetic screens. These new tools will make it possible to identify new and innovative classes of anticancer drugs, including those that show synthetic lethal interactions with cancer-specific mutations.
Insights
Understanding gene function is key to cancer research. New high-throughput screening technologies help identify gene functions and novel anticancer drugs, especially those targeting cancer-specific mutations.
Area of Science:
- Genetics and Genomics
- Cancer Biology
- Molecular Biology
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