Related Experiment Video

Updated: Aug 30, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Immunotherapy for prostate cancer

Lawrence Fong1, Eric J Small

  • 1Department of Medicine, University of California, San Francisco, CA 94143, USA.

Seminars in Oncology
|October 23, 2003
PubMed

Insights

Novel immunotherapies, including tumor vaccines, show promise for advanced prostate cancer by targeting specific antigens like PSA, PAP, and PSMA. These approaches leverage T cell recognition for improved clinical efficacy.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Androgen deprivation therapy has been the standard for advanced prostate cancer for decades.
  • Emerging research focuses on novel immunotherapeutic strategies to complement existing treatments.

Purpose of the Study:

  • To explore the potential of immunotherapies for advanced prostate cancer.
  • To identify and utilize prostate-specific antigens as targets for novel treatment approaches.

Main Methods:

  • Identification of antigens recognized by T cells in prostate cancer.
  • Utilizing proteins like prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), and prostate-specific membrane antigen (PSMA) as immunologic targets.
  • Leveraging advancements in cancer genomics and proteomics for target discovery.

Main Results:

  • Immunotherapy trials have demonstrated immunogenicity and clinical efficacy in prostate cancer.
  • Specific antigens (PSA, PAP, PSMA) have been successfully targeted for immunotherapy.

Conclusions:

  • Understanding immune recognition and antigen presentation is key to developing effective prostate cancer immunotherapies.
  • Future research will focus on building upon current findings to enhance immunotherapy efficacy.

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...