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Sugar/steroid/sugar conjugates: sensitivity of lipid binding to sugar structure
Bessie N A Mbadugha1, Fredric M Menger
1Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
Organic Letters
|October 24, 2003
Abstract:
[structure: see text]. Three steroids, each bearing a sugar on rings A and D, have been synthesized. Their effect on the "melting" behavior of a lipid bilayer depends on whether the sugar is glucose, galactose, or mannose. Packing constraints dictate how the lipid bilayer responds to the sugars.