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A new beta-carbolinone synthesis using a Rh(II)-promoted [3 + 2]-cycloaddition and Pd(0) cross-coupling/Heck
1Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
Organic Letters
|October 24, 2003
Abstract:
[reaction: see text]. A short and efficient synthesis of the beta-carbolinone ring system was achieved using a rhodium(II)-catalyzed [3 + 2]-cycloaddition, a Pd(0)-catalyzed C-N amination reaction, and a subsequent intramolecular Heck reaction as the key synthetic steps.