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Updated: Aug 30, 2026

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
Published on: September 7, 2010
Inhibition of influenza A virus sialidase activity by sulfatide
Takashi Suzuki1, Tadanobu Takahashi, Daisuke Nishinaka
1Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, 422-8526 Shizuoka, Japan. suzukit@ys7.u-shizuoka-ken.ac.jp
Abstract:
Sulfatide, which binds to influenza A viruses and prevents the viral infection, was found to inhibit the sialidase activities of influenza A viruses in a pH-dependent manner. The kinetic parameters of the effect of sulfatide on the sialidase activities of human influenza A viruses using fluorometric assay indicated that sulfatide was a powerful and non-competitive type inhibitor in low-pH conditions.
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