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Influence of low high-density lipoprotein cholesterol on left ventricular hypertrophy and diastolic function in

Takeshi Horio1, Junko Miyazato, Kei Kamide

  • 1Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan. thorio@ri.ncvc.go.jp

American Journal of Hypertension
|October 24, 2003
PubMed

Insights

Low high-density lipoprotein (HDL) cholesterol is linked to adverse left ventricular (LV) changes in hypertension patients. This study found low HDL cholesterol independently predicts LV hypertrophy and diastolic dysfunction in essential hypertension.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Lipid Metabolism

Background:

  • Left ventricular (LV) hypertrophy and diastolic dysfunction are common in hypertensive patients, influenced by various factors.
  • The specific role of serum lipids, particularly high-density lipoprotein (HDL) cholesterol, in hypertensive heart disease remains understudied.
  • While low HDL cholesterol is a known coronary heart disease risk factor, its impact on hypertension-related cardiac changes is unclear.

Purpose of the Study:

  • To investigate the relationship between dyslipidemia, specifically low HDL cholesterol, and LV structural and functional changes in patients with treated essential hypertension.
  • To determine if serum lipid profiles are associated with LV hypertrophy and diastolic dysfunction in this patient cohort.

Main Methods:

  • Echocardiography (two-dimensional and Doppler) was used to assess LV mass, atrial to early diastolic filling ratio (A/E), and E-wave deceleration time in 274 hypertensive patients.
  • Statistical analyses, including univariate and multiple regression, were employed to examine the associations between lipid levels and LV parameters.
  • The study specifically focused on the impact of low HDL cholesterol on LV structure and diastolic function.

Main Results:

  • Univariate analysis revealed an inverse association between HDL cholesterol and LV mass, A/E ratio, and deceleration time.
  • Low HDL cholesterol was significantly associated with LV diastolic function in both genders and LV mass in women.
  • Multiple regression analysis identified low HDL cholesterol as the sole independent predictor of both LV mass and diastolic dysfunction among the lipid parameters evaluated.

Conclusions:

  • Low HDL cholesterol levels appear to be an independent risk factor for unfavorable modifications in left ventricular structure and diastolic function in patients with treated essential hypertension.
  • These findings highlight the potential importance of managing HDL cholesterol levels to mitigate cardiac remodeling in hypertensive individuals.
Abstract

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