Related Experiment Video
Updated: Aug 30, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
Published on: October 20, 2020
Delivering the vaccination mail
1Department of Bioengineering, Box 351721, University of Washington, Seattle, WA 98195, USA. stayton@u.washington.edu
Abstract:
The impact of preventative and therapeutic vaccines continues to expand in the fields of infectious disease and cancer, but their full potential is currently limited by drug-delivery challenges. Synthetic delivery systems that incorporate principles of biological design could improve vaccine efficacy significantly. A recent paper by Murthy et al. demonstrates that microgels engineered on the nano-scale and designed to degrade at the mildly acidic pH of the phagosomal compartment can enhance protein-antigen entry into the cytoplasmic major histocompatibility complex (MHC) class 1 processing pathway.
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