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Updated: Aug 10, 2026

A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer (SMPS-ICPMS)
Published on: July 11, 2017
New mathematical models with associated equations for isotope dilution mass spectrometry (IDMS)
Heinrich Kipphardt1, Paul De Bièvre, Philip D P Taylor
1Bundesanstalt für Materialforschung und -prüfung (BAM), 12200 Berlin, Germany. heinrich.kipphardt@bam.de
Abstract:
Vector models which progressively lead to a general model for isotope dilution mass spectrometry (IDMS) are presented for the case of two 'monitor isotopes' and one blend involved. They enable one to find the boundary conditions for performing IDMS, and cover the cases of highly enriched isotopes, radioactive isotopes and ratios that are given with different denominator. The models identify the key measurements in their simplest form as well as the conditions which minimise the measurement effort and in some cases the propagated measurement uncertainties. The equations are discussed and compared with other published IDMS equations. Combined with discussion on fundamental aspects of IDMS, this results in an even more 'general' but also more complex IDMS equation.
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