Related Experiment Video
Updated: Aug 30, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
Acetaldehyde adducts in the brain of alcoholics
Kazuhiko Nakamura1, Kazuhiko Iwahashi, Aizo Furukawa
1Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama Hamamatsu-shi, 431-3192 Shizuoka, Japan. nakamura@hama-med.ac.jp
Abstract:
Acetaldehyde binds to some proteins and becomes a Schiff base. It is assumed that after the consumption of ethanol the acetaldehyde binds to the proteins to form adducts, and such acetaldehyde adducts are associated with organ diseases. We investigated the detection of acetaldehyde adducts in the brain region of a human alcoholics. Brain samples collected from an alcoholic autopsied case were used. Determination of acetaldehyde adducts was performed using a fluorescence immmunohistochemical staining method with antibodies against acetaldehyde adducts. We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics.
More Related Videos
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Aldehydes and Ketones with Alcohols: Hemiacetal Formation
Acid-Catalyzed Aldol Addition Reaction
Acid Halides to Esters: Alcoholysis
Hepatic Encephalopathy
Alzheimer Disease ll: Pathophysiology

