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Vascular remodeling by intussusceptive angiogenesis.
Valentin Djonov1, Oliver Baum, Peter H Burri
1Institute of Anatomy, University of Bern, Bühlstrasse 26, CH-3012, Bern, Switzerland. djonov@ana.unibe.ch
Cell and Tissue Research
|October 24, 2003
Summary
Intussusception is a rapid blood vessel growth method that remodels existing endothelial cells. This process efficiently expands the capillary network without extensive cell proliferation, offering therapeutic potential.
Area of Science:
- Vascular Biology
- Cell Biology
- Physiology
Background:
- Intussusception is an alternative to sprouting angiogenesis for microvascular growth.
- It involves the protrusion of microvascular walls into the capillary lumen, forming a transluminal pillar.
- This process is crucial for vascular growth and remodeling.
Purpose of the Study:
- To describe the mechanism and implications of intussusceptive angiogenesis.
- To highlight its role in capillary plexus expansion, hierarchical tree formation, and branching remodeling.
- To emphasize its advantages over sprouting angiogenesis for therapeutic development.
Main Methods:
- Observational analysis of microvascular wall interactions.
- Description of endothelial cell rearrangement and pillar formation.
- Identification of myofibroblast and pericyte involvement.
Main Results:
- Intussusception facilitates rapid capillary plexus expansion for metabolic exchange.
- It enables intussusceptive arborization, creating a hierarchical vascular tree.
- Intussusceptive branching remodeling optimizes vessel geometry and allows for pruning.
Conclusions:
- Intussusception is an efficient, rapid vascular growth mechanism.
- It remodels existing endothelial cells, avoiding extensive proliferation and tissue disruption.
- Understanding intussusception can lead to new pro- and anti-angiogenic therapies.