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[Preliminary study on gene expression profile of endometrial adenocarcinoma]
Huai-jun Zhou1, Yi-fu Shi, Juan-qing Li
1Department of Gynecology, Women's Hospital, Medical Collage, Zhejiang University, Hangzhou 310006, China.
Objective:
To determine candidate genes of endometrial adenocarcinoma.
Methods:
To compare the gene expression profile in 2 endometrial adenocarcinoma tissues and 2 normal endometria by HGEC-40s GeneChip probe including 4096 genes array. Expression differences between normal and malignant tissue groups were measured by GenePixPro3.0 software.
Results:
350 genes with a ratio below 0.5 and above 2.0 showed discrimination between normal and malignant groups. Thirty three genes with ratio above 3 were up-regulated, forty-four genes with ratio below 0.3 were down-regulated.
Conclusion:
The overexpression of oncogenes with their disturbed or constitutively activated signal transduction cascades alone or in combination with the mutation-induced silencing of tumor suppressor genes is associated with malignant transformation.