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[Multivariate analysis of recurrence in T1 bladder transitional cell carcinoma]
Jun Zhang1, Li Zeng, Gui-zhong Li
1First Hospital, Institute of Urology of Peking University, Beijing 100034, China.
Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]
|October 25, 2003
Summary
Tumor multifocality and abnormal expression of p53 and E-cadherin independently predict recurrence in T1 bladder cancer. These findings aid in better risk stratification for patients with transitional cell carcinoma (TCC).
Area of Science:
- Uro-oncology
- Cancer biomarkers
- Prognostic factors
Context:
- Transitional cell carcinoma (TCC) is the most common type of bladder cancer.
- Accurate prognostic markers are crucial for managing T1 bladder TCC, a stage with significant recurrence rates.
Purpose:
- To evaluate the prognostic significance of clinicopathologic factors and specific biomarkers in predicting recurrence of T1 bladder TCC.
- To identify independent predictors of disease recurrence in this patient cohort.
Summary:
- This study analyzed 75 patients with T1 bladder TCC, assessing p53, E-cadherin, and VEGF expression alongside clinicopathologic features.
- Recurrence-free survival rates at 1, 3, and 5 years were 68.0%, 45.3%, and 20.9%, respectively.
- Multivariate analysis identified tumor multifocality, and aberrant expression of p53 and E-cadherin as independent predictors of recurrence.
Impact:
- The findings highlight the utility of tumor multifocality, p53, and E-cadherin as independent prognostic indicators for T1 bladder TCC.
- This can improve patient risk stratification and guide treatment decisions, potentially reducing recurrence rates.