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Updated: Aug 7, 2026
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Synthesis, characterization and biological properties of a novel copper complex
Surajit Majumder1, Gouri Sankar Panda, Soumitra Kumar Choudhuri
1Department of Environmental Carcinogenesis and Toxicology (ECT), Chittaranjan National Cancer Institute (CNCI), 37 S.P. Mukherjee Road, Calcutta 700 026, India.
Abstract:
The study of copper complex in relation to cancer is important in many ways. A novel copper complex has been synthesized with non toxic ligand, viz. potassium salt of N-(2-hydroxy acetophenone) glycinate (NHAG). The structure of the complex has been determined by spectroscopic means. Toxicity and antitumor property of the complex has been studied in vivo. Though the complex is toxic at higher doses, lower non toxic doses of the complex deplete glutathione (GSH). GSH depleting property of the complex may be utilized to sensitize drug resistant cells where resistance is due to elevated level of GSH.
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