Jove
Visualize
Contact Us

Related Experiment Videos

Persistent fever in association with infective endocarditis.

E A Blumberg1, N Robbins, A Adimora

  • 1Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 1, 1992
PubMed
Summary

Persistent fever in endocarditis patients despite antibiotics often signals complications. This study highlights that prolonged fever indicates serious issues, requiring further evaluation and intervention for better outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correspondence analysis to evaluate the transmission of Staphylococcus aureus strains in two New York State maximum-security prisons.

Epidemiology and infection·2017
Same author

Zika Virus in Transplantation: Emerging Infection and Opportunities.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Successful treatment of a disseminated infection with extensively drug-resistant Klebsiella pneumoniae in a liver transplant recipient with a fosfomycin-based multidrug regimen.

Transplant infectious disease : an official journal of the Transplantation Society·2016
Same author

Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Just Say No: Stemming the Tide of Antibiotic Overprescription.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

It's not too late: a proposal to standardize the terminology of "late-onset" cytomegalovirus infection and disease in solid organ transplant recipients.

Transplant infectious disease : an official journal of the Transplantation Society·2016
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Internal Medicine

Background:

  • Persistent fever despite appropriate antimicrobial therapy for endocarditis is a concerning clinical sign.
  • Endocarditis is a serious infection of the heart valves or lining.

Purpose of the Study:

  • To evaluate the significance and implications of persistent fever in patients with endocarditis.
  • To identify common causes and complications associated with prolonged fever in endocarditis.

Main Methods:

  • Retrospective review of patients with endocarditis and prolonged fever (> or = 2 weeks) at three hospital affiliates.
  • Comparison with a matched cohort of endocarditis patients without prolonged fever.
  • Analysis of fever duration, causes, cardiac involvement, surgical interventions, complications, and mortality.

Related Experiment Videos

Main Results:

  • Persistent fever in endocarditis patients was associated with longer fever duration (median 35 days) and cardiac complications like myocardial abscesses.
  • Higher rates of cardiac surgery (16 vs. 2) and nosocomial complications (22 vs. 5) were observed in the persistent fever group.
  • Mortality was higher in patients with persistent fever (6 vs. 0), primarily due to endocarditis-related complications.

Conclusions:

  • Persistent fever in endocarditis frequently indicates complicated disease, including cardiac abscesses and increased risk of surgery and nosocomial infections.
  • An approach for evaluating patients with persistent fever in endocarditis is presented.
  • Prompt recognition and thorough evaluation are crucial for managing complicated endocarditis.