Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in primary palate and midface morphogenesis research.

V M Diewert1, K Y Wang

  • 1Department of Clinical Dental Sciences, University of British Columbia, Vancouver.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|January 1, 1992
PubMed
Summary

Primary palate development involves critical cellular events and craniofacial growth timing. Delays in these processes, like mesenchymal bridge formation, can lead to cleft lip malformations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Research progress on the pathogenesis and clinical treatment of cirrhotic cardiomyopathy].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2026
Same author

[The application of robot-assisted laparoscopic resection of primary retroperitoneal tumors via the abdominal approach].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
Same author

[Study on the diagnostic value of fetal magnetic resonance imaging of external ear abnormalities].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Statistical analysis methods for identifying multimorbidity patterns].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[The best preferable sagittal vertical axis for the ankylosis spondylitis with thoracolumbar kyphosis following one-level pedicle subtraction osteotomy under different cervical range of motion].

Zhonghua yi xue za zhi·2025
Same author

[Role of intercellular adhesion molecule-1 in adhesion and migration of mesenchymal stem cells in ankylosing spondylitis and its mechanisms].

Zhonghua yi xue za zhi·2024

Area of Science:

  • Developmental biology
  • Craniofacial development
  • Embryology

Background:

  • Primary palate formation is crucial for facial development.
  • Cleft lip is a common congenital malformation with complex etiology.
  • Understanding normal palate development aids in identifying causes of malformations.

Purpose of the Study:

  • To analyze primary palate development phases in human and mouse embryos.
  • To define normal morphological phases and identify alterations leading to cleft lip.
  • To compare developmental processes between cleft lip and noncleft strains.

Main Methods:

  • Analysis of human embryos from the Carnegie Embryology Collection.
  • Analysis of mouse embryos from cleft lip and noncleft strains.

Related Experiment Videos

  • Comparative study of craniofacial growth and palate development phases.

    • Main Results:

    • Human and mouse embryos exhibit similar primary palate development phases: nasal fin formation followed by mesenchymal bridge development.
    • A robust mesenchymal bridge is essential before midfacial growth separates facial components.
    • Mouse strains with cleft lip gene showed delayed maxillary growth, nasal fin formation, and mesenchymal replacement.

    Conclusions:

    • Successful primary palate formation requires a precise sequence of cellular events timed with craniofacial growth.
    • Alterations in these timed events during a critical developmental period can result in cleft lip.
    • Comparative embryological studies provide insights into mechanisms of congenital malformations.