Jove
Visualize
Contact Us

Related Experiment Videos

Artificial cells in immobilization biotechnology.

T M Chang1

  • 1Artificial Cells & Organs Research Centre, Faculty of Medicine, McGill University, Montreal, P.Q., Canada.

Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology
|January 1, 1992
PubMed
Summary

Artificial cells are being used in various medical treatments, including hemoperfusion for poisoning and metal toxicity. These cells are also being tested in animals for diabetes and liver failure treatment. A new method prevents rejection of transplanted cells. Artificial cells containing enzymes are being studied for hereditary deficiency diseases and amino acid metabolism. Oral administration of artificial cells can alter amino acid levels in the intestine. These cells also help convert waste products into essential amino acids. Artificial cells are also used to produce biotechnological products like monoclonal antibodies and interferons. Their use in drug delivery and other applications is being explored.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators.

QJM : monthly journal of the Association of Physicians·2020
Same author

Propentdyopent: the scaffold of a heme metabolite as an electron reservoir in transition metal complexes.

Chemical communications (Cambridge, England)·2016
Same author

Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver.

Oncogene·2013
Same author

Microencapsulation of enzymes, cells, and genetically engineered microorganisms.

Methods in molecular medicine·2011
Same author

Structure and dynamics of N,N-diethyl-N-methylammonium triflate ionic liquid, neat and with water, from molecular dynamics simulations.

The journal of physical chemistry. A·2010
Same author

Neurohormonal control of exocrine pancreas.

Current opinion in gastroenterology·2006
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biotechnology applications in medical treatment
  • Cell encapsulation in therapeutic research
  • Enzyme-based bioprocessing in chemical engineering

Background:

Current medical treatments rely on artificial cells to deliver biologically active materials. These cells have been used in hemoperfusion to treat poisoning and metal toxicity. However, limitations remain in their application for chronic diseases like diabetes and liver failure. While enzyme-containing artificial cells have been proposed for hereditary deficiencies, their full potential is not yet realized. Oral administration of amino acid-depleting artificial cells is a recent development. The ability to convert waste products into essential amino acids is a promising area of research. Artificial cells are also being explored for producing monoclonal antibodies and interferons. Their use in drug delivery and biotechnology is expanding, but challenges remain in long-term stability and targeted delivery.

Purpose Of The Study:

This study aims to evaluate the use of artificial cells in various medical and biotechnological applications. The focus is on hemoperfusion, enzyme therapy, and cell encapsulation for chronic diseases. The goal is to assess the effectiveness of artificial cells in treating poisoning and metal toxicity. The study also investigates their role in amino acid metabolism and waste conversion. The purpose includes exploring artificial cells for monoclonal antibody production. Researchers are examining their potential in drug delivery systems. The study highlights the need for improved methods to prevent xenograft rejection. The ultimate aim is to expand the therapeutic and industrial applications of artificial cells.

Keywords:
Artificial cellsBiomedical applicationsHemoperfusionEnzyme therapyCell encapsulation

Frequently Asked Questions

Artificial cells in hemoperfusion remove toxins like aluminum and iron from the blood.

Artificial cells containing enzymes may replace missing enzymes in patients with hereditary deficiencies.

The two-step method prevents rejection of transplanted cells in xenograft experiments.

Artificial cells can deplete specific amino acids in the intestine through oral administration.

Related Experiment Videos

Main Methods:

Artificial cells were developed using encapsulation techniques to contain biologically active materials. Hemoperfusion devices were tested in clinical settings for poisoning and metal toxicity. Animal models were used to evaluate artificial cells in diabetes and liver failure treatment. A two-step method was employed to reduce xenograft rejection. Enzyme-containing artificial cells were studied for hereditary deficiency diseases. Oral administration of amino acid-depleting artificial cells was tested in the intestine. Waste conversion systems using complex enzyme systems were analyzed. Production of monoclonal antibodies and interferons was monitored in artificial cell cultures.

Main Results:

Artificial cells containing adsorbents effectively removed toxins in hemoperfusion trials. Encapsulated cell cultures showed promise in treating diabetes and liver failure in animals. The two-step method reduced xenograft rejection in experimental models. Enzyme-containing artificial cells demonstrated activity in hereditary deficiency diseases. Oral administration of amino acid-depleting artificial cells altered intestinal metabolism. Waste conversion systems successfully produced essential amino acids from urea and ammonia. Artificial cells supported the production of monoclonal antibodies and interferons. These findings suggest artificial cells have broad applications in biotechnology and medicine.

Conclusions:

Artificial cells offer a versatile platform for medical and biotechnological applications. Their use in hemoperfusion and enzyme therapy has shown clinical benefits. Encapsulated cell cultures may provide new treatment options for chronic diseases. The two-step method improves the viability of xenografts in experimental models. Oral administration of artificial cells alters amino acid metabolism in the intestine. Waste conversion systems demonstrate potential for amino acid production. Artificial cells support biotechnological product synthesis, including monoclonal antibodies. These findings suggest artificial cells can expand therapeutic and industrial applications.

Enzyme systems in artificial cells convert urea and ammonia into essential amino acids.

Artificial cells are used to produce monoclonal antibodies and interferons.