Related Experiment Videos
[IgM type multiple myeloma expressing various surface adhesion molecules and demonstrating an aggressive clinical
Yasuo Hirayama1, Sumio Sakamaki, Yasushi Tsuji
1Department of Internal Medicine, Higashi Sapporo Hospital.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 28, 2003
Summary
This case report details a rare instance of IgM myeloma with plasmacytoma in a 70-year-old woman. Despite treatment, the patient succumbed to complications, highlighting the aggressive nature of this rare plasma cell disorder.
Area of Science:
- Hematology
- Oncology
Background:
- IgM myeloma is a rare subtype of plasma cell dyscrasias.
- Plasmacytoma is a localized tumor of plasma cells.
Observation:
- A 70-year-old female presented with anemia, elevated total protein, and an axillary mass.
- Imaging revealed a cranial lesion and a chest tumor.
- Biopsy confirmed plasmacytoma with cytoplasmic IgM; bone marrow showed increased plasma cells.
Findings:
- Immunophenotype analysis revealed cytoplasmic IgM, kappa light chains, and expression of CD5, CD38, CD11a, CD44, CD49d, and CD54.
- Diagnosis: IgM myeloma associated with plasmacytoma.
- Chemotherapy regimens (melphalan/prednisolone, VAD) showed limited efficacy.
Implications:
- This is the first reported case of plasmacytoma associated with IgM myeloma.
- The immunophenotype provides insights into this rare malignancy.
- The case underscores the challenges in treating aggressive IgM myeloma.