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Updated: Aug 30, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
Published on: March 9, 2012
A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis
1Department of Biochemistry, Case Western Reserve School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Abstract:
When growth factors are removed from many mammalian cells, growth ceases and apoptosis is induced. The small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediating the regulated internalization and degradation of nutrient transporters. This process triggers nutrient starvation that helps to induce cell death.
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