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Published on: June 20, 2014
Synthesis and anticonvulsant activities of 4-N-substituted arylsemicarbazones
Surendra N Pandeya1, Sonia Kohli, Nadeem Siddique
1University of Pharmaceutics, Institute of Technology, Banams Hindu University, Varanasi--221005, India. snpandeya@rediffmail.com
Abstract:
A series of 4-N-substituted arylsemicarbazones with increased lipophilicity were synthesized and evaluated for anticonvulsant activity. The compounds provided significant protection against maximal electroshock induced seizures (MES) and seizures indicated by sc pentetrazole administration (sc PTZ) at 300 mg/kg after 0.5 h. The compounds 8 and 4 were active in MES and sc PTZ indicated seizure. The study has shown that introduction of alkyl (ethyl) at the terminal amino group and alkoxy (methoxy) moiety at the distal aryl ring led to increased activity and decreased toxicity.
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