[The effect of clofelin on uterine contractile activity (experimental and clinical research)]

Pregnant rat experiments have revealed a pronounced and prolonged naloxone-irreversible depriming effect of clofelin, 0.05 and 0.5 mg/kg, on the frequency and amplitude of myometrial biopotentials, which was eliminated with phenoxybenzamine. In clinical testing, clofelin in therapeutical doses showed a marked tocolytic effect in threatened abortion at 18-34-week gestation. The agent in the same doses normalized blood pressure in hypertensive pregnants, without having a negative action on the fetus.