Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic presynaptic varicosities: a role in activity-dependent synaptogenesis.

Dominique Muller1, Irina Nikonenko

  • 1Neuropharmacology, Centre Médical Universitaire, 1211 4, Geneva, Switzerland. dominique.muller@medecine.unige.ch

Trends in Neurosciences
|October 31, 2003
PubMed
Summary

Neuronal activity enhances synaptic plasticity by increasing the turnover of both presynaptic and postsynaptic structures. This dynamic remodeling leads to a reorganization of synaptic circuitry over time.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

To Believe or Not to Believe in Conspiracy Claims? That Is a Question for Signal Detection Theory.

Psychological science·2026
Same author

Measuring the semantic priming effect across many languages.

Nature human behaviour·2025
Same author

Radiolysis of myoglobin concentrated gels by protons: specific changes in secondary structure and production of carbon monoxide.

Scientific reports·2024
Same author

Improving physical activity using a single personalized consequence-based approach-avoidance training: Effects on self-reported behaviors, attitudes, and choices.

Psychology of sport and exercise·2023
Same author

Kinetics <i>vs.</i> thermodynamics: walking on the line for a five-fold increase in MnSi Curie temperature.

Materials horizons·2023
Same author

Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.

Nature communications·2022

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • Confocal imaging reveals synaptic structures are dynamic.
  • Synapse formation and elimination are activity-dependent.
  • Dendritic spine turnover occurs in the somatosensory cortex following sensory stimulation.

Purpose of the Study:

  • To investigate the dynamic remodeling of presynaptic structures.
  • To understand how neuronal activity influences synaptic turnover at both pre- and postsynaptic levels.
  • To elucidate the mechanisms underlying synaptic circuitry reorganization.

Main Methods:

  • Utilized advanced confocal imaging techniques.
  • Observed synaptic structure dynamics in response to neuronal activity.
  • Analyzed correlated remodeling of presynaptic elements.

Related Experiment Videos

Main Results:

  • Synaptic structures exhibit motility and continuous turnover.
  • Neuronal activation significantly enhances synapse formation and elimination.
  • Evidence of correlated remodeling in presynaptic structures was found.
  • Activity-driven dynamics occur at both presynaptic and postsynaptic sites.

Conclusions:

  • Neuronal network activation promotes dynamic changes at both presynaptic and postsynaptic levels.
  • Enhanced synaptic turnover results in the reorganization of synaptic circuitry.
  • These findings highlight the activity-dependent nature of synaptic plasticity and circuit refinement.