'Neuro'-peptides in glia: focus on NPY and galanin

The term neuropeptide was advanced by de Wied and collaborators in the early seventies. At that time, they defined neuropeptides as endogenous substances synthesized in nerve cells and involved in nervous system functions. Since then, several studies have revealed that the very same 'neuropeptides' are also expressed in non-neuronal cells. It is therefore generally accepted that the original definition of these peptides was too limited and, consequently, it has recently been revised. Among the non-neuronal cells that synthesize neuropeptides are several glial cell types.